Pure devotional service to the Lord uproots one’s material desires.

Although pious religious work, truthfulness, mercy, penances and knowledge partially purify one’s existence, they do not take out the root of material desires. Thus the same desires will reappear at a later time. After an extensive program of material gratification, one becomes eager to perform austerities, acquire knowledge, perform selfless work and in general purify one’s existence. After sufficient piety and purification, however, one again becomes eager for material enjoyment. When clearing an agricultural field one must uproot the unwanted plants, otherwise with the coming of rain everything will grow back as it was. Pure devotional service to the Lord uproots one’s material desires, so that there is no danger of relapsing into a degraded life of material gratification. In the eternal kingdom of God, loving reciprocation between the Lord and His devotees is manifest. One who has not come to this stage of enlightenment must remain on the material platform, which is always full of discrepancies and contradictions. Thus everything is incomplete and imperfect without loving service to the Lord.

Source: A.C. Bhaktivedanta Swami Prabhupada (2014 edition), “Srimad Bhagavatam”, Eleventh Canto, Chapter 14 – Text 22.