A devotee should not be overly depressed or morose but to remain enthusiastic and to go on with his loving service.
The beginning stage of pure devotional service is described here by the Lord. A sincere devotee has practically seen that all material activities lead only to sense gratification and all sense gratification leads only to misery. Thus a devotee’s sincere desire is to engage twenty-four hours a day in the loving service of Lord Kṛṣṇa without any personal motivation. The devotee sincerely desires to be established in his constitutional position as the Lord’s eternal servitor, and he prays to the Lord to elevate him to this exalted position. The word anīśvara indicates that because of one’s past sinful activities and bad habits one may not immediately be able to completely extinguish the enjoying spirit. The Lord here encourages such a devotee not to be overly depressed or morose but to remain enthusiastic and to go on with his loving service. The word nirviṇṇa indicates that a sincere devotee, although somewhat entangled in the remnants of sense gratification, is completely disgusted with material life and under no circumstances willingly commits sinful activities. In fact, he avoids every kind of materialistic activity. The word kāmān basically refers to sex attraction and its by-products in the form of children, home and so forth. Within the material world, the sex impulse is so strong that even a sincere candidate in the loving service of the Lord may sometimes be disturbed by sex attraction or by lingering sentiments for wife and children. A pure devotee certainly feels spiritual affection for all living entities, including the so-called wife and children, but he knows that material bodily attraction leads to no good, for it simply entangles one and one’s so-called relatives in a miserable chain reaction of fruitive activities. The word dṛḍha-niścaya (“steadfast conviction”) indicates that in any circumstance a devotee is completely determined to go on with his prescribed duties for Kṛṣṇa. Thus he thinks, “By my previous shameful life my heart is polluted with many illusory attachments. Personally I have no power to stop them. Only Lord Kṛṣṇa within my heart can remove such inauspicious contamination. But whether the Lord removes such attachments immediately or lets me go on being afflicted by them, I will never give up my devotional service to Him. Even if the Lord places millions of obstacles in my path, and even if because of my offenses I go to hell, I will never for a moment stop serving Lord Kṛṣṇa. I am not interested in mental speculation and fruitive activities; even if Lord Brahmā personally comes before me offering such engagements, I will not be even slightly interested. Although I am attached to material things I can see very clearly that they lead to no good because they simply give me trouble and disturb my devotional service to the Lord. Therefore, I sincerely repent my foolish attachments to so many material things, and I am patiently awaiting Lord Kṛṣṇa’s mercy.”
Source: A.C. Bhaktivedanta Swami Prabhupada (2014 edition), “Srimad Bhagavatam”, Eleventh Canto, Chapter 20 – Text 27-28.