Materially alert and ambitious persons are constantly in anxiety.
Those who fervently seek material sense gratification are gradually pushed down into a miserable condition of life because as soon as one even slightly violates the laws of nature, one must suffer sinful reactions. Thus even materially alert and ambitious persons are constantly in anxiety, and from time to time they are plunged into great misery. Those who are nonsensical and retarded, however, live in a fool’s paradise, and those who have surrendered to Lord Kṛṣṇa are filled with transcendental bliss. Therefore both the fool and the devotee may be said to be peaceful, in the sense that they are free from the ordinary anxiety of the materially ambitious person. However, this does not mean that the devotee and the retarded fool are on the same platform. A fool’s peace is like that of a dead stone, whereas a devotee’s satisfaction is based on perfect knowledge.
Source: A.C. Bhaktivedanta Swami Prabhupada (2014 edition), “Srimad Bhagavatam”, Eleventh Canto, Chapter 09 – Text 04.