It is most difficult to separate the material mind from its objects.
“It is most difficult to separate the material mind from its objects because the material mind by definition considers itself to be the doer and enjoyer of everything. It must be understood that giving up the material mind does not mean giving up all mental activities, but instead means purifying the mind and engaging one’s enlightened mentality in the devotional service of the Lord. Since time immemorial the material mind and senses have been in contact with the sense objects; therefore, how is it possible for the material mind to give up its objects, which are the basis of its existence? And not only does the mind reach out to material objects, but also, because of the mind’s desires, the material objects cannot remain out of the mind, helplessly entering at every moment. Thus, separation between the mind and sense objects is not actually feasible, nor does it serve any purpose. If one retains a material mentality, considering oneself to be supreme, one may renounce sense gratification, considering it to be ultimately the cause of unhappiness, but one will not be able to remain on such an artificial platform, nor will such renunciation serve any real purpose. Without surrender to the lotus feet of the Lord, mere renunciation cannot take one out of this material world.
Just as the sun’s rays are part of the sun, the living entities are part of the Supreme Personality of Godhead. When the living entity is completely absorbed in his identity as the part and parcel of the Personality of Godhead, he becomes actually wise and easily gives up the material mind and sense objects. The word mad-rūpaḥ in this verse indicates absorption of the mind in the form, qualities, pastimes and associates of the Supreme Personality of Godhead. Immersed in such ecstatic meditation, one should render devotional service to the Lord, and this will automatically drive away the influence of sense gratification. By himself, the living entity does not have the potency to give up his false identification with the material mind and sense objects, but by worshiping the Lord in the mood of being His eternal part-and-parcel servant, one is infused with the Lord’s potency, which easily drives away the darkness of ignorance.”
Source: A.C. Bhaktivedanta Swami Prabhupada (2014 edition), “Srimad Bhagavatam”, Eleventh Canto, Chapter 13 – Text 26.